Article-Journal

Adaptive graph learning of microbial phylogeny enables accurate and interpretable microbiome-based host phenotype prediction

Biao Dong, Bin Wang, Jiongjin Chen, Xiaomin Xu, Zhenjiang Zech Xu

Conserved 3′ stem-loop structures enable comprehensive analysis of bacterial transcription termination in metagenomes

Bacterial transcription termination is a critical yet underexplored layer of gene regulation in microbial ecosystems. Existing …

Yunfan Jin, Jiyun Cui, Rulong Liu, Hongli Ma, Xiaomin Xu, Shufang Wu, Fei Gan, Zhi John Lu, Zhenjiang Zech Xu

Natural carrier-free self-assembled binary polyphenol nanoparticles remodel the gut microenvironment for inflammatory bowel disease prevention

Developing biocompatible, multi-target therapeutics remains a critical challenge in the management of inflammatory bowel disease (IBD). …

Qiwen Xie, Huan Xu, Xiaoming Yang, Ying Chen, Zhenjiang Zech Xu

Dietary Nisin Exacerbates Diabetic Vascular Complications through Gut Microbiota Modulation and NF-κB Signaling

Diabetic vascular complications (DVCs) are a major cause of morbidity in diabetes, with gut microbiota dysbiosis emerging as an …

Liting Liu, Yong Huang, Huan Xu, Yifan Sun, Zhenjiang Zech Xu, Xiaochang Huang

Decoding Oral Leukoplakia: Microbiome Dysbiosis and Inflammatory Dynamics Unveiled in a Rat Model

Introduction: Oral leukoplakia (OLK) is an oral precancerous lesion associated with oral microbiome dysbiosis and systemic …

Zhiqin Sang, Yufeng Zhang, Enoch Kao, Tingting Zhu, Jiazhen Yang, Zhenjiang Zech Xu, Shi Huang, Fei Teng, Wanchun Wang

Survival and Safety Evaluation of Bifidobacterium Longum Subsp. Longum ZS-8 in Healthy Adults, Determined Using PMAxx-qPCR and Amplicon Sequencing

Species-level quantitative PCR (qPCR) provides in-depth knowledge of oral probiotics in the human gastrointestinal tract (GIT). …

Feng Liu, Biao Dong, Zhongsun Wang, Dan Lin, Huan Xu, Baisheng Ke, Wanying Kang, Yang Jin, Xiuting Huang, Hui Lu, Liqing Zhao, Yun Qian, Liangling Cai, Long Xu, Zhenjiang Zech Xu

RNA–ligand interaction scoring via data perturbation and augmentation modeling

Despite recent advances in RNA-targeting drug discovery, the development of data-driven deep learning models remains challenging owing …

Hongli Ma, Letian Gao, Yunfan Jin, Jianwei Ma, Yilan Bai, Xiaofan Liu, Pengfei Bao, Ke Liu, Zhenjiang Zech Xu, Zhi John Lu